|Planning and management of aircraft pavement construction. - Smith, Timothy.|
|Validation of the mine impact burial model using experimental data. - Smith, Timothy Brian.|
Thesis advisor(s): Chu, Peter C.
|Hydrogen-powered flight - Smith, Timothy D|
As the Nation moves towards a hydrogen economy the shape of aviation will change dramatically. To accommodate a switch to hydrogen the aircraft designs, propulsion, and power systems will look much different than the systems of today. Hydrogen will enable a number of new aircraft capabilities from high altitude long endurance remotely operated aircraft (HALE ROA) that will fly weeks to months without refueling to clean, zero emissions transport aircraft...
Keywords: COMMUNICATION; ACTS; ASYNCHRONOUS TRANSFER MODE; PROTOCOL (COMPUTERS); COMMERCE; EXTREMELY HIGH FREQUENCIES; INTERNETS; INTEROPERABILITY; TRANSPARENCE
|The attenuation of flexural waves in mass loaded beams. - Smith, Timothy L.|
Available from National Technical Information Service, Springfield, Va
Keywords: Naval architecture; Mechanical engineering
|VariVis: a visualisation toolkit for variation databases. (Volume 9) - Smith, Timothy D|
This article is from BMC Bioinformatics, volume 9.AbstractBackground: With the completion of the Human Genome Project and recent advancements in mutation detection technologies, the volume of data available on genetic variations has risen considerably. These data are stored in online variation databases and provide important clues to the cause of diseases and potential side effects or resistance to drugs...
|Application of circular consensus sequencing and network analysis to characterize the bovine IgG repertoire. (Volume 13) - Larsen, Peter A|
This article is from BMC Immunology, volume 13.AbstractBackground: Vertebrate immune systems generate diverse repertoires of antibodies capable of mediating response to a variety of antigens. Next generation sequencing methods provide unique approaches to a number of immuno-based research areas including antibody discovery and engineering, disease surveillance, and host immune response to vaccines...
|SNP discovery in swine by reduced representation and high throughput pyrosequencing. (Volume 9) - Wiedmann, Ralph T|
This article is from BMC Genetics, volume 9.AbstractBackground: Relatively little information is available for sequence variation in the pig. We previously used a combination of short read (25 base pair) high-throughput sequencing and reduced genomic representation to discover > 60,000 single nucleotide polymorphisms (SNP) in cattle, but the current lack of complete genome sequence limits this approach in swine...
|Yellowstone National Park: Submerged Resources Survey - Bradford, James; Russell, Matthew; Murphy, Larry; Smith, Timothy|
|Rigid Bronchoscopic Removal of Multiple Airway Foreign Bodies. (Volume 4) - Lano, Charles F.|
This article is from Diagnostic and Therapeutic Endoscopy, volume 4.AbstractDespite new equipment, such as the Hopkins rod-lens telescopes and optical forceps, foreign bodies in the airway continue to present a diagnostic and therapeutic challenge to the endoscopist. Airway foreign bodies are more common in children than adults and frequently, the patient may have aspirated more than one foreign body or the original foreign body fragments into pieces...
|Experimental Evaluation of a Subscale Gaseous Hydrogen/Gaseous Oxygen Coaxial Rocket Injector - Smith, Timothy D.|
The next generation reusable launch vehicle may utilize a Full-Flow Stage Combustion (FFSC) rocket engine cycle. One of the key technologies required is the development of an injector that uses gaseous oxygen and gaseous hydrogen as propellants. Gas-gas propellant injection provides an engine with increased stability margin over a range of throttle set points. This paper summarizes an injector design and testing effort that evaluated a coaxial rocket injector for use with gaseous oxygen and gase...
Keywords: NUMERICAL ANALYSIS; ELECTRONIC STRUCTURE; MOLECULES; STABILITY; DYNAMIC MODELS; RARE GAS COMPOUNDS; WAVE FUNCTIONS; ATOMS; BENDING; DECOMPOSITION; DISSOCIATION
|Feasibility comparison and analysis of the Unix network environment and the Windows NT environment for integration with the Defense Information Infrastructure (DII) - Sauer, Mark F.;Smith, Timothy J.;Sprague, John W.;Staier, Joseph E.|
Thesis advisor(s): Norman Schneidewind, James C. Emery
|Performance of an Axisymmetric Rocket Based Combined Cycle Engine During Rocket Only Operation Using Linear Regression Analysis - Smith, Timothy D.|
The all rocket mode of operation is shown to be a critical factor in the overall performance of a rocket based combined cycle (RBCC) vehicle. An axisymmetric RBCC engine was used to determine specific impulse efficiency values based upon both full flow and gas generator configurations. Design of experiments methodology was used to construct a test matrix and multiple linear regression analysis was used to build parametric models...
Keywords: CERAMICS; FIBER COMPOSITES; SILICON CARBIDES; JOINTS (JUNCTIONS); BONDING; AEROSPACE SYSTEMS; HIGH TEMPERATURE
|A treatise of health and long life, with the sure means of attaining it : in two books - Lessius, Leonardus, 1554-1623|
"A treatise on the benefits of a sober life : Written originally in Italian by Lewis Cornaro, a noble Venetian. Translated into Latin, by Leonard Lessius; and now into English, by T.S. ... London, MDCCLXVII:" 38 p. at end
Keywords: Hygiene; Longevity
|Single nucleotide polymorphism discovery in rainbow trout by deep sequencing of a reduced representation library. (Volume 10) - Sanchez, Cecilia Castano|
This article is from BMC Genomics, volume 10.AbstractBackground: To enhance capabilities for genomic analyses in rainbow trout, such as genomic selection, a large suite of polymorphic markers that are amenable to high-throughput genotyping protocols must be identified. Expressed Sequence Tags (ESTs) have been used for single nucleotide polymorphism (SNP) discovery in salmonids. In those strategies, the salmonid semi-tetraploid genomes often led to assemblies of paralogous sequences and therefore...
|Prion gene haplotypes of U.S. cattle. (Volume 7) - Clawson, Michael L|
This article is from BMC Genetics, volume 7.AbstractBackground: Bovine spongiform encephalopathy (BSE) is a fatal neurological disorder characterized by abnormal deposits of a protease-resistant isoform of the prion protein. Characterizing linkage disequilibrium (LD) and haplotype networks within the bovine prion gene (PRNP) is important for 1) testing rare or common PRNP variation for an association with BSE and 2) interpreting any association of PRNP alleles with BSE susceptibility...
|Linkage mapping bovine EST-based SNP. (Volume 6) - Snelling, Warren M|
This article is from BMC Genomics, volume 6.AbstractBackground: Existing linkage maps of the bovine genome primarily contain anonymous microsatellite markers. These maps have proved valuable for mapping quantitative trait loci (QTL) to broad regions of the genome, but more closely spaced markers are needed to fine-map QTL, and markers associated with genes and annotated sequence are needed to identify genes and sequence variation that may explain QTL...
|Ovine reference materials and assays for prion genetic testing. (Volume 6) - Heaton, Michael P|
This article is from BMC Veterinary Research, volume 6.AbstractBackground: Genetic predisposition to scrapie in sheep is associated with several variations in the peptide sequence of the prion protein gene (PRNP). DNA-based tests for scoring PRNP codons are essential tools for eradicating scrapie and for evaluating rare alleles for increased resistance to disease. In addition to those associated with scrapie, there are dozens more PRNP polymorphisms that may occur in various flocks...
|MicroRNA transcriptome profiles during swine skeletal muscle development. (Volume 10) - McDaneld, Tara G|
This article is from BMC Genomics, volume 10.AbstractBackground: MicroRNA (miR) are a class of small RNAs that regulate gene expression by inhibiting translation of protein encoding transcripts. To evaluate the role of miR in skeletal muscle of swine, global microRNA abundance was measured at specific developmental stages including proliferating satellite cells, three stages of fetal growth, day-old neonate, and the adult...
|Circulating mediators of bone remodeling in psoriatic arthritis: implications for disordered osteoclastogenesis and bone erosion. (Volume 12) - Dalbeth, Nicola|
This article is from Arthritis Research & Therapy, volume 12.AbstractIntroduction: Diverse bone pathologies are observed in patients with psoriatic arthritis (PsA). Uncoupling of bone remodeling with disordered osteoclastogenesis has been implicated in the pathogenesis of PsA. The aim of this study was to examine the role of soluble mediators of bone remodeling within the circulation of patients with PsA...
|Reducing assembly complexity of microbial genomes with single-molecule sequencing. (Volume 14) - Koren, Sergey|
This article is from Genome Biology, volume 14.AbstractBackground: The short reads output by first- and second-generation DNA sequencing instruments cannot completely reconstruct microbial chromosomes. Therefore, most genomes have been left unfinished due to the significant resources required to manually close gaps in draft assemblies. Third-generation, single-molecule sequencing addresses this problem by greatly increasing sequencing read length, which simplifies the assembly problem...
|The artiodactyl APOBEC3 innate immune repertoire shows evidence for a multi-functional domain organization that existed in the ancestor of placental mammals. (Volume 9) - LaRue, Rebecca S|
This article is from BMC Molecular Biology, volume 9.AbstractBackground: APOBEC3 (A3) proteins deaminate DNA cytosines and block the replication of retroviruses and retrotransposons. Each A3 gene encodes a protein with one or two conserved zinc-coordinating motifs (Z1, Z2 or Z3). The presence of one A3 gene in mice (Z2–Z3) and seven in humans, A3A-H (Z1a, Z2a-Z1b, Z2b, Z2c-Z2d, Z2e-Z2f, Z2g-Z1c, Z3), suggests extraordinary evolutionary flexibility...
|Characterization of 954 bovine full-CDS cDNA sequences. (Volume 6) - Harhay, Gregory P|
This article is from BMC Genomics, volume 6.AbstractBackground: Genome assemblies rely on the existence of transcript sequence to stitch together contigs, verify assembly of whole genome shotgun reads, and annotate genes. Functional genomics studies also rely on transcript sequence to create expression microarrays or interpret digital tag data produced by methods such as Serial Analysis of Gene Expression (SAGE)...
|Small ruminant lentivirus genetic subgroups associate with sheep TMEM154 genotypes. (Volume 44) - Sider, Lucia H|
This article is from Veterinary Research, volume 44.AbstractSmall ruminant lentiviruses (SRLVs) are prevalent in North American sheep and a major cause of production losses for the U.S. sheep industry. Sheep susceptibility to SRLV infection is influenced by genetic variation within the ovine transmembrane 154 gene (TMEM154). Animals with either of two distinct TMEM154 haplotypes that both encode glutamate at position 35 of the protein (E35) are at greater risk of SRLV infection than those homozy...
|Phylogenetic classification of Escherichia coli O157:H7 strains of human and bovine origin using a novel set of nucleotide polymorphisms. (Volume 10) - Clawson, Michael L|
This article is from Genome Biology, volume 10.AbstractNovel SNPs from human and bovine O157:H7 E. coli isolates are mapped, revealing that the majority of human disease is caused by a bovine subset of this strain.
|An atlas of bovine gene expression reveals novel distinctive tissue characteristics and evidence for improving genome annotation. (Volume 11) - Harhay, Gregory P|
This article is from Genome Biology, volume 11.AbstractBackground: A comprehensive transcriptome survey, or gene atlas, provides information essential for a complete understanding of the genomic biology of an organism. We present an atlas of RNA abundance for 92 adult, juvenile and fetal cattle tissues and three cattle cell lines. Results: The Bovine Gene Atlas was generated from 7.2 million unique digital gene expression tag sequences (300.2 million total raw tag sequences), from which 1.59 mil...
|Phylogeny of Shiga Toxin-Producing Escherichia coli O157 Isolated from Cattle and Clinically Ill Humans. (Volume 29) - Bono, James L.|
This article is from Molecular Biology and Evolution, volume 29.AbstractCattle are a major reservoir for Shiga toxin-producing Escherichia coli O157 (STEC O157) and harbor multiple genetic subtypes that do not all associate with human disease. STEC O157 evolved from an E. coli O55:H7 progenitor; however, a lack of genome sequence has hindered investigations on the divergence of human- and/or cattle-associated subtypes...
|Association, effects and validation of polymorphisms within the NCAPG - LCORL locus located on BTA6 with feed intake, gain, meat and carcass traits in beef cattle. (Volume 12) - Lindholm-Perry, Amanda K|
This article is from BMC Genetics, volume 12.AbstractBackground: In a previously reported genome-wide association study based on a high-density bovine SNP genotyping array, 8 SNP were nominally associated (P ≤ 0.003) with average daily gain (ADG) and 3 of these were also associated (P ≤ 0.002) with average daily feed intake (ADFI) in a population of crossbred beef cattle. The SNP were clustered in a 570 kb region around 38 Mb on the draft sequence of bovine chromosome 6 (BTA6), an interval c...
|Complete Closed Genome Sequences of Four Mannheimia varigena Isolates from Cattle with Shipping Fever. (Volume 2) - Harhay, Gregory P.|
This article is from Genome Announcements, volume 2.AbstractMannheimia varigena is an occasional respiratory pathogen of cattle and pigs. We present the first four complete closed genome sequences of this species.
|Complete Closed Genome Sequences of Three Bibersteinia trehalosi Nasopharyngeal Isolates from Cattle with Shipping Fever. (Volume 2) - Harhay, Gregory P.|
This article is from Genome Announcements, volume 2.AbstractBibersteinia trehalosi is a respiratory pathogen affecting cattle and related ruminants worldwide. B. trehalosi is closely related to Mannheimia haemolytica and is often associated with bovine respiratory disease complex (BRDC), a polymicrobial multifactorial disease. We present three complete closed genome sequences of this species generated using an automated assembly pipeline.
|Complete Closed Genome Sequences of Mannheimia haemolytica Serotypes A1 and A6, Isolated from Cattle. (Volume 1) - Harhay, Gregory P.|
This article is from Genome Announcements, volume 1.AbstractMannheimia haemolytica is a respiratory pathogen affecting cattle and related ruminants worldwide. M. haemolytica is commonly associated with bovine respiratory disease complex (BRDC), a polymicrobial multifactorial disease. We present the first two complete closed genome sequences of this species, determined using an automated assembly pipeline requiring no manual finishing.
|Integrating linkage and radiation hybrid mapping data for bovine chromosome 15. (Volume 5) - Snelling, Warren M|
This article is from BMC Genomics, volume 5.AbstractBackground: Bovine chromosome (BTA) 15 contains a quantitative trait loci (QTL) for meat tenderness, as well as several breaks in synteny with human chromosome (HSA) 11. Both linkage and radiation hybrid (RH) maps of BTA 15 are available, but the linkage map lacks gene-specific markers needed to identify genes underlying the QTL, and the gene-rich RH map lacks associations with marker genotypes needed to define the QTL...
|A deletion mutation in bovine SLC4A2 is associated with osteopetrosis in Red Angus cattle. (Volume 11) - Meyers, Stacey N|
This article is from BMC Genomics, volume 11.AbstractBackground: Osteopetrosis is a skeletal disorder of humans and animals characterized by the formation of overly dense bones, resulting from a deficiency in the number and/or function of bone-resorbing osteoclast cells. In cattle, osteopetrosis can either be induced during gestation by viral infection of the dam, or inherited as a recessive defect...
|Prevalence of the prion protein gene E211K variant in U.S. cattle. (Volume 4) - Heaton, Michael P|
This article is from BMC Veterinary Research, volume 4.AbstractBackground: In 2006, an atypical U.S. case of bovine spongiform encephalopathy (BSE) was discovered in Alabama and later reported to be polymorphic for glutamate (E) and lysine (K) codons at position 211 in the bovine prion protein gene (Prnp) coding sequence. A bovine E211K mutation is important because it is analogous to the most common pathogenic mutation in humans (E200K) which causes hereditary Creutzfeldt – Jakob disease, an ...
|Comparative analysis of tandem repeats from hundreds of species reveals unique insights into centromere evolution. (Volume 14) - Melters, Daniel P|
This article is from Genome Biology, volume 14.AbstractBackground: Centromeres are essential for chromosome segregation, yet their DNA sequences evolve rapidly. In most animals and plants that have been studied, centromeres contain megabase-scale arrays of tandem repeats. Despite their importance, very little is known about the degree to which centromere tandem repeats share common properties between different species across different phyla...
|A second generation radiation hybrid map to aid the assembly of the bovine genome sequence. (Volume 7) - Jann, Oliver C|
This article is from BMC Genomics, volume 7.AbstractBackground: Several approaches can be used to determine the order of loci on chromosomes and hence develop maps of the genome. However, all mapping approaches are prone to errors either arising from technical deficiencies or lack of statistical support to distinguish between alternative orders of loci. The accuracy of the genome maps could be improved, in principle, if information from different sources was combined to produce integrated maps...
|A physical map of the bovine genome. (Volume 8) - Snelling, Warren M|
This article is from Genome Biology, volume 8.AbstractA new physical map of the bovine genome has been constructed by integrating data from genetic and radiation hybrid maps, and a new bovine BAC map, with the bovine genome draft assembly.